Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.

A Markowska, D Bartulewicz, A Pućkowska, A Rózański

Index: Rocz. Akad. Med. Bialymst. 42(1) , 129-40, (1997)

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Abstract

A carbocyclic analogue of distamycin was obtained, in which the N-methylpyrrole rings were substituted by disubstituted benzene rings. Additionally, N-chloro- or N-bromoacetyl groups, displaying alkylating properties, were introduced. The synthesis, starting from 3,5-dinitrobenzoyl chloride, consisted of five stages.