Tetrahedron

Friedel–Crafts acylation reaction using carboxylic acids as acylating agents

M Kawamura, DM Cui, S Shimada

Index: Kawamura, Masato; Cui, Dong-Mei; Shimada, Shigeru Tetrahedron, 2006 , vol. 62, # 39 p. 9201 - 9209

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Citation Number: 66

Abstract

Dehydrative Friedel–Crafts acylation reaction of aromatic compounds with carboxylic acids as acylating agents was investigated in the presence of Lewis acid-or Brønsted acid- catalyst. Various metal triflates and bis (trifluoromethanesulfonyl) amides showed catalytic activity at high temperature, among which Eu (NTf2) 3 proved to be the most effective and efficiently catalyzed the acylation reaction of alkyl-and alkoxybenzenes with aliphatic and ...