Reaction of 1??alkynyl thiocyanates with nucleophilic reagents. Synthesis of 2, 4??disubstituted 1, 3??thiazoles

RLP de Jong, J Meijer, RS Sukhai…

Index: Jong, R.L.P. de; Meijer, J.; Sukhai, R.S.; Bradsma, L. Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 9 p. 310 - 313

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Abstract

Abstract Reaction of 1-alkynyl thiocyanates RC≡ CSC≡ N (1) with alcohols, phenol or thiols or secondary aliphatic amines in the presence of anhydrous zinc chloride or boron trifluoride diethyl etherate gives mixtures of 2, 4-disubstituted 1, 3-thiazoles (2), thiocarbonyl