Synlett

Conversion of nucleophilic halides to electrophilic halides: Efficient and selective halogenation of azinones, amides, and carbonyl compounds using metal halide/lead …

…, DH Kweon, SD Cho, HK Kim, SG Lee, YJ Yoon

Index: Kim, Jeum-Jong; Kweon, Deok-Heon; Cho, Su-Dong; Kim, Ho-Kyun; Lee, Sang-Gyeong; Yoon, Yong-Jin Synlett, 2006 , # 2 p. 194 - 200

Full Text: HTML

Citation Number: 19

Abstract

Abstract AlCl 3/Pb (OAc) 4 and ZnBr 2/Pb (OAc) 4 are efficient electrophilic N-and α-C- halogenating agents. A variety of azinones, amides and carbonyl compounds were chemoselectively and regioselectively N-, or α-C-halogenated in good to excellent yield using AlCl 3/Pb (OAc) 4 and ZnBr 2/Pb (OAc) 4 in acetonitrile.