Life Sciences 2013-05-01

Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate.

Xi-ChunMay Lu, JitendraR Dave, Zhiyong Chen, Ying Cao, Zhilin Liao, FrankC Tortella

Index: Life Sci. 92(22) , 1055-63, (2013)

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Abstract

Stroke patients are at a high risk of developing post-ischemic seizures and cognitive impairment. Nefiracetam (NEF), a pyrrolidone derivative, has been shown to possess both anti-epileptic and cognitive-enhancing properties. In this study the anti-seizure effects of NEF were evaluated in a rat model of post-ischemic nonconvulsive seizures (NCSs). Its potential mechanisms were investigated in neuronal cell culture assays of neurotoxicity associated with ischemic brain injury and epileptogenesis.