European Journal of Pharmacology 1976-03-01

Butyrophenone influences on the opiate receptor.

I Creese, A P Feinberg, S H Snyder

Index: Eur. J. Pharmacol. 36(1) , 231-5, (1976)

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Abstract

Interaction of neuroleptic drugs with the opiate receptors was investigated by inhibition of the stereospecific binding of 3H-naloxone. Benperidol and pimozide, with IC50's of 0.3-0.5 muM, were more potent than the classical opiates meperidine and propoxyphene. A systematic structure-activity relationship was evident with the basic opiate structure of a benzene and a piperidine ring preserved in active compounds. No correlation between neuroleptic activity and binding to the opiate receptor was demonstrated.