Brain Research 1998-10-05

Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food intake in the neonatal chick.

M Furuse, T Bungo, M Shimojo, Y Masuda, N Saito, S Hasegawa, K Sugahara

Index: Brain Res. 807(1-2) , 214-7, (1998)

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Abstract

Recently, the suppressive effect on food intake by the central administration of glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the central nervous system was suggested, though the role for C-terminal amino acids in the central nervous system has not been reported. The present study was done to elucidate the central effect of N-terminal fragments of GLP-1(7-36) on food intake of the neonatal chick. Intracerebroventricular (i.c.v.) administration of mammalian GLP-1(7-36) inhibited food intake of chicks, but the fragments of GLP-1(7-16) and GLP-1(7-26) did not show the suppressive effect on food intake. Furthermore, the extended fragments, GLP-1(7-30) and GLP-1(7-33), also had no effects on food intake. It is concluded that C-terminal amino acids of GLP-1(7-36) have an important role for the bioactivity in the central nervous system with special reference to feeding behavior.Copyright 1998 Elsevier Science B.V.