Infection and Immunity 2005-07-01

Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells.

Alexander Ploss, An Tran, Ewa Menet, Ingrid Leiner, Eric G Pamer

Index: Infect. Immun. 73(7) , 4423-6, (2005)

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Abstract

H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.