e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of pharmaceutical sciences

Mechanism of hydrolysis and structure–stability relationship of enaminones as potential prodrugs of model primary amines

VH Naringrekar, VJ Stella

Index: Journal of Pharmaceutical Sciences, , vol. 79, # 2 p. 138 - 146

Full Text: HTML

Citation Number: 62

Abstract

... and Molar Absorptlvltlaa (r,J Values tor Some Enamlnoner ___ Enaminone A-, nm Yrn f SD, M-' 2a 322.0 21 200 +. ... Scheme II For reaction conditions where [H'] >> K,, eq 2 collapses to eq 3: 142 I Journal of Pharmaceutical Sciences Vol. 79, No. 2, February 1990 ...

Ethyl 3-anilinocrotonate Structure

Ethyl 3-anilino...

~%

Ethyl acetoacetate Structure

Ethyl acetoacetate

Structure

3-anilino-5,5-dimethyl-2-cyclohexen-1-one Structure

3-anilino-5,5-d...

~%

Dimedone Structure

Structure

4-(2-phenylethylamino)pent-3-en-2-one Structure

4-(2-phenylethy...

~%

2-Phenylethanamine Structure

2-Phenylethanamine

2,4-Pentandione Structure

2,4-Pentandione

ethyl 2-anilinocyclopentene-1-carboxylate Structure

ethyl 2-anilino...

~%

Ethyl 2-oxocyclopentanecarboxylate Structure

Ethyl 2-oxocycl...

Structure

ethyl 2-anilinocyclohexene-1-carboxylate Structure

ethyl 2-anilino...

~%

Structure

Ethyl 2-oxocyclohexanecarboxylate Structure

Ethyl 2-oxocycl...

4-PHENYLAMINO-3-PENTEN-2-ONE Structure

4-PHENYLAMINO-3...

~%

Structure

2,4-Pentandione Structure

2,4-Pentandione

AC-L-Val-OH Structure

~%

DL-Valine Structure

2,4-Pentandione Structure

2,4-Pentandione

4-(2-phenylethylamino)pent-3-en-2-one Structure

4-(2-phenylethy...

~%

2-Phenylethanamine Structure

2-Phenylethanamine

2,4-Pentandione Structure

2,4-Pentandione

4-anilino-2-methyl-2,3-dihydropyran-6-one Structure

4-anilino-2-met...

~%

5,6-dihydro-4-hydroxy-6-methyl-2h-pyran-2-one Structure

5,6-dihydro-4-h...

Structure

Simple, fast and efficient synthesis of β-keto esters from t...

[Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197]

Simple, fast and efficient synthesis of β-keto esters from t...

[Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197]

Simple, fast and efficient synthesis of β-keto esters from t...

[Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197]

Simple, fast and efficient synthesis of β-keto esters from t...

[Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197]

Simple, fast and efficient synthesis of β-keto esters from t...

[Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197]