Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines

…, K Rajesh, BP Reddy, S Karthikeyan, NS Kumari

Index: Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197

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Abstract

A series of β-keto esters were synthesized from heteroaryl esters and ethyl acetate using LiHMDS as base at− 50 to− 30° C. The increase in yields of cross condensed product were observed and the percentage of self condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent and the minimum amount of ethyl acetate. All these β- keto esters were characterized using 1H NMR, 13C NMR and mass spectral data. A ...