Canadian Journal of Chemistry

The reduction of aryl trifluoromethyl ketones by sodium borohydride. The hydride transfer process

R Stewart, KC Teo

Index: Stewart, Ross; Teo, K. C. Canadian Journal of Chemistry, 1980 , vol. 58, p. 2491 - 2496

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Citation Number: 26

Abstract

The rates of reduction of 17 aryl trifluoromethyl ketones by sodium borohydride in 2- propanol have been measured. The rho (ρ) value is+ 3.12, excluding the 4-amino and 4- dimethylamino groups, which both lower the rate to a greater extent than their σ values predict. The close correspondence between substituent effects for hydride addition in the methyl and trifluoromethyl series (excluding the amino groups) suggests that normal ...