e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Organic letters

An amino alcohol ligand for highly enantioselective addition of organozinc reagents to aldehydes: serendipity rules

WA Nugent

Index: Organic Letters, , vol. 4, # 13 p. 2133 - 2136

Full Text: HTML

Citation Number: 69

Abstract

... Volume: Page: ... Organic Letters. ... a All reactions contained aldehyde (3.0 mmol), Et 2 Zn (6.0 mmol), amino alcohol (1R,2S)-4 (0.15 mmol), and tert-butylbenzene as internal standard (300 μL) in 2:1 hexane−toluene (9 mL) at room temperature for 3 h except as ...

Diethylzinc Structure

4-Chlorobenzaldehyde Structure

4-Chlorobenzaldehyde

~%

(R)-1-(4-CHLOROPHENYL)-1-PROPANOL Structure

(R)-1-(4-CHLORO...

p-chlorobenzylalcohol Structure

p-chlorobenzyla...

Diethylzinc Structure

Ethanoic anhydride Structure

Ethanoic anhydride

Hexanal Structure

~0%

N/A Structure

Detail

Diethylzinc Structure

Cyclohexanecarboxaldehyde Structure

Cyclohexanecarb...

~%

(1R)-1-cyclohexylpropan-1-ol Structure

(1R)-1-cyclohex...

Cyclohexylmethanol Structure

Cyclohexylmethanol

Diethylzinc Structure

p-Tolualdehyde Structure

~%

p-tolylmethanol Structure

p-tolylmethanol

1-(4-Methylphenyl)-1-propanol Structure

1-(4-Methylphen...

Methylpropenal Structure

Diethylzinc Structure

~%

(R)-3-hydroxy-2-methylpent-1-ene Structure

(R)-3-hydroxy-2...

N/A Structure

Detail

Diethylzinc Structure

m-Tolualdehyde Structure

~%

3-Methylbenzyl alcohol Structure

3-Methylbenzyl ...

1-(3-Methylphenyl)-1-propanol Structure

1-(3-Methylphen...

Diethylzinc Structure

Hexanal Structure

~%

3-Octyl alcohol Structure

3-Octyl alcohol

3-Octyl alcohol Structure

3-Octyl alcohol

Detail

Diethylzinc Structure

Cyclohexanecarboxaldehyde Structure

Cyclohexanecarb...

~%

(R)-(+)-2,2-dimethyl-3-pentanol Structure

(R)-(+)-2,2-dim...

Neopentyl alcohol Structure

Neopentyl alcohol

Diethylzinc Structure

Isobutyraldehyde Structure

Isobutyraldehyde

~%

isobutanol Structure

(+)-(R)-2-methyl-3-pentanol Structure

(+)-(R)-2-methy...

Preparation, characterization and use of 1, 3-disulfonic aci...

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Novel and facile selective reduction of carboxylic acid with...

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N-Methylpyrrolidine-zinc borohydride: As a new stable and ef...

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