Organic Letters 2006-02-02

Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.

Jasmina Nikodinovic, Jennifer M Dinges, Stephen C Bergmeier, Mark C McMills, Dennis L Wright, Nigel D Priestley

Index: Org. Lett. 8(3) , 443-5, (2006)

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Abstract

[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can be manipulated by switching from aerobic to anaerobic growth, thereby generating both enantiomers of the target in excellent yield and enantiomeric purity.