The Synthesis and Biological activity of a Highly Selective Adenosine A2a. Receptor Agonist

DR Borcherding, NL Lentz, PM Weintraub…

Index: Borcherding, David R.; Lentz, Nelsen L.; Weintraub, Philip M.; Dudley, Mark W.; Secrest, Roberta; Kastner, Philip R.; Peet, Norton P. Nucleosides and Nucleotides, 1999 , vol. 18, # 10 p. 2175 - 2191

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Citation Number: 5

Abstract

Abstract Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.