A solution phase synthesis of the anticoagulant decapeptide Suc-Tyr-Glu-Pro-Ile-Pro-Glu- Glu-Ala-Cha-D-Glu-OH (1, MDL 28050) on a large scale is described. Our strategy employed in the 24-step total synthesis relies on a convergent approach. The basic feature is the preparation and the coupling of two protected pentapeptides, 2 and 3. Several key intermediates were purified by crystallizations including the protected decapeptide 21. ...
