Organic & Biomolecular Chemistry 2014-01-14

Rapid access to α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products.

Xiaofei Zhang, Qian He, Haoyue Xiang, Shanshan Song, Zehong Miao, Chunhao Yang

Index: Org. Biomol. Chem. 12(2) , 355-61, (2014)

Full Text: HTML

Abstract

An effective and convenient method has been developed for the preparation of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile in the presence of zinc dust, acetic acid and triethylamine. This protocol presents a simple, rapid and pot/step economical strategy for preparing biologically interesting α-carbolines with moderate anti-tumor activities.