Journal of Organic Chemistry 2007-02-16

Syntheses of novel chiral sulfinamido ligands and their applications in diethylzinc additions to aldehydes.

Zhiyan Huang, Hongshan Lai, Yong Qin

Index: J. Org. Chem. 72(4) , 1373-8, (2007)

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Abstract

A novel class of sulfinamido alcohol ligands 1-6 was synthesized from (S)-tert-butanesulfinamide. These ligands showed excellent catalytic activities and enantiomeric selectivities in asymmetric additions of diethylzinc to aromatic aldehydes.