Chemical Communications 2011-08-28

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.

Jiang Qian, Chananat Klomsiri, Marcus W Wright, S Bruce King, Allen W Tsang, Leslie B Poole, Cristina M Furdui

Index: Chem. Commun. (Camb.) 47(32) , 9203-5, (2011)

Full Text: HTML

Abstract

Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.