Synthesis of Ketones from α??Oxocarboxylates and Aryl Bromides by Cu/Pd??Catalyzed Decarboxylative Cross??Coupling

…, F Rudolphi, C Oppel, N Rodriguez

Index: Goossen, Lukas J.; Rudolphi, Felix; Oppel, Christoph; Rodriguez, Nuria Angewandte Chemie - International Edition, 2008 , vol. 47, # 16 p. 3043 - 3045

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Citation Number: 206

Abstract

Aryl ketones are important structural elements in biologically active compounds and functional materials.[1] Besides Friedel–Crafts acylations,[2] which yield these products mostly as isomeric mixtures, the reaction of activated carboxylic acid derivatives with organometallic reagents,[3] eg of Weinreb amides with Grignard compounds, is most often used for their preparation.[4] Transition-metal catalysts increase the efficiency of such ...