Tetrahedron Letters

Copper-mediated direct arylation of benzoazoles with aryl iodides

T Yoshizumi, H Tsurugi, T Satoh, M Miura

Index: Yoshizumi, Tomoki; Tsurugi, Hayato; Satoh, Tetsuya; Miura, Masahiro Tetrahedron Letters, 2008 , vol. 49, # 10 p. 1598 - 1600

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Citation Number: 113

Abstract

In our previous work, we found that addition of a copper(I) species, typically CuI, can effectively enhance the above palladium-catalyzed direct arylation in some cases. 3a It was also observed that the reaction of azoles with aryl iodides can proceed to some extent at the 2-position selectively by using the much less expensive copper species alone as a promoter. The copper-mediated method has been applied to the synthesis of 2-arylated imidazoles including ...