The Journal of organic chemistry

Copper-catalyzed synthesis of benzoxazoles via a regioselective C− H functionalization/C− O bond formation under an air atmosphere

S Ueda, H Nagasawa

Index: Ueda, Satoshi; Nagasawa, Hideko Journal of Organic Chemistry, 2009 , vol. 74, # 11 p. 4272 - 4277

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Citation Number: 127

Abstract

An efficient method for the synthesis of functionalized benzoxazoles is described that involves a copper (II)-catalyzed regioselective C− H functionalization/C− O bond formation protocol. The use of dichlorobenzene as a solvent at 160° C allows the use of air as the terminal oxidant in the catalytic synthesis of benzoxazoles in a process that has high functional group tolerance. The presence of a directing group at the meta position ...

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