Journal of Organic Chemistry 2007-12-21

The decarboxylative Blaise reaction.

Jae Hoon Lee, Bo Seung Choi, Jay Hyok Chang, Hee Bong Lee, Joo-Yong Yoon, Jaeick Lee, Hyunik Shin

Index: J. Org. Chem. 72(26) , 10261-3, (2007)

Full Text: HTML

Abstract

Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided beta-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride.