Organic Letters 2006-05-11

Synthesis of functionalized organotrifluoroborates via halomethyltrifluoroborates.

Gary A Molander, Jungyeob Ham

Index: Org. Lett. 8 , 2031, (2006)

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Abstract

[reaction: see text] Potassium bromo- and iodomethyltrifluoroborates have been prepared via in situ reaction of n-BuLi with dibromo- and diiodomethane, respectively, in the presence of trialkyl borates, followed by treatment with KHF(2). Moreover, a new synthetic method for the preparation of potassium organotrifluoroborates through nucleophilic substitution of the halide in these potassium halomethyltrifluoroborates is described.