Chemical Communications 2005-09-07

Simple iron-amine catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing beta-hydrogens.

Robin B Bedford, Duncan W Bruce, Robert M Frost, Michael Hird

Index: Chem. Commun. (Camb.) (33) , 4161-3, (2005)

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Abstract

Mixtures of iron(III) chloride and appropriate amine ligands are active catalysts for the coupling of aryl Grignard reagents with primary and secondary alkyl halide substrates bearing beta-hydrogens, under mild and simple reaction conditions.