The Journal of Urology 2010-01-01

Protective effect of palmitoylethanolamide, a naturally-occurring molecule, in a rat model of cystitis

Federica Pessina, Raffaele Capasso, Francesca Borrelli, Teresa Aveta, Lorena Buono, Giuseppe Valacchi, Paolo Fiorenzani, Vincenzo Di Marzo, Pierangelo Orlando, Angelo A. Izzo

Index: J. Urol. 193(4) , 1401-8, (2015)

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Abstract

Purpose Palmitoylethanolamide is both an endogenous mediator released together with the endocannabinoid anandamide from membrane phospholipids, and a plant-derived compound with analgesic and antinflammatory properties. Here, we verified if the pathophysiology of experimental cystitis involves changes in the levels of palmitoylethanolamide and of some of its targets [i.e. cannabinoid (CB1 and CB2) receptors, and PPARα] and if exogenous-administered palmitoylethanolamide can be proposed as a preventive measure for cystitis.