Chemical Communications 2009-04-28

Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes.

Lachlan S Campbell-Verduyn, Leila Mirfeizi, Rudi A Dierckx, Philip H Elsinga, Ben L Feringa

Index: Chem. Commun. (Camb.) 16 , 2139-2141, (2009)

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Abstract

Monodentate phosphoramidite ligands are used to accelerate the copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(i) and Cu(ii) salts both function as the copper source in aqueous solution to provide excellent yields.