British Journal of Pharmacology 1984-09-01

Quinine blocks a calcium-activated potassium conductance in mammalian enteric neurones.

E Cherubini, R A North, A Surprenant

Index: Br. J. Pharmacol. 83(1) , 3-5, (1984)

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Abstract

Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred without any effect on the amplitude or time course of the action potential itself, or on the faster calcium-independent afterhyperpolarization. Tetraethylammonium did not reduce the slow afterhyperpolarization. Quinine also abolished the hyperpolarization which was evoked by intracellular injection of calcium ions.