Macromolecular Bioscience 2015-08-01

Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.

Ryan J Seelbach, Peter Fransen, Daniel Pulido, Matteo D'Este, Fabian Duttenhoefer, Sebastian Sauerbier, Thomas M Freiman, Philipp Niemeyer, Fernando Albericio, Mauro Alini, Miriam Royo, Alvaro Mata, David Eglin

Index: Macromol. Biosci. 15 , 1035-44, (2015)

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Abstract

BMP-2 and TGF-β1 released from injectable thermoresponsive hydrogels are studied in the presence and absence of branched macromolecules bearing BMP-2 or TGF-β1 affinity binding peptides. The synthesized branched macromolecules and the gelling compositions before and after loading with either BMP-2 or TGF-β1 are characterized physico-chemically and show a significantly lower amount of proteins released in the presence of the affinity binding peptide macromolecules. This study illustrates the potential of affinity binding peptide functionalized dendrimers to modulate the local delivery and availability of growth factors important for musculoskeletal regeneration therapies. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.