Toxicology Letters 2013-06-20

Microglial disruption in young mice with early chronic lead exposure

Christina Sobin, Mayra Gisel Flores Montoya, Natali Parisi, Tanner Schaub, Miguel Cervantes, Rodrigo X. Armijos

Index: Toxicol. Lett. 220(1) , 44-52, (2013)

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Abstract

• Neuroinflammatory markers and microglia were compared in young mice with and without early chronic Pb exposure. • Mice with Pb levels from 2.66 to 20.31μg/dL had dose-dependent reduction of cytokine IL6. • Mice with Pb levels from 2.66 to 20.31μg/dL had dose-dependent reduction of detectable microglia. • No evidence of increased neuroinflammation was found.