Journal of Combinatorial Chemistry 2010-09-13

Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water.

Zhan-Hui Zhang, Hong-Yan Lü, Shu-Hong Yang, Jian-Wu Gao

Index: J. Comb. Chem. 12(5) , 643-6, (2010)

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Abstract

A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride, amines, and aldehydes in water using magnetically recoverable Fe(3)O(4) nanoparticles is reported. This methodology results in the synthesis of a variety of 2,3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst can be recovered and recycled without a significant loss in the catalytic activity.