Pharmaceutica Acta Helvetiae 1998-12-01

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.

V Mishra, S N Pandeya, E DeClercq, C Pannecouque, M Witvrouw

Index: Pharm. Acta Helv. 73(4) , 215-8, (1998)

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Abstract

The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (HTLV-IIIB) and -HIV-2 (ROD) activity and cytotoxicity of the compounds were tested. The compound VII and VIII showed maximum protection among the series.