Antimicrobial Agents and Chemotherapy 2007-03-01

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Poonpilas Hongmanee, Kamolchanok Rukseree, Benjamas Buabut, Boontiwa Somsri, Prasit Palittapongarnpim

Index: Antimicrob. Agents Chemother. 51 , 1105-6, (2007)

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Abstract

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.