Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach

S Lucas, R Heim, M Negri, I Antes, C Ries…

Index: Ono, Aoi; Suzuki, Nobuko; Kamimura, Junko Synthesis, 1987 , # 8 p. 736 - 738

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Citation Number: 65

Abstract

... In the present study, we describe the design and synthesis of a series of 3-benzyl ... of a series of heteroaryl-substituted methyleneindanes(12, 13) and naphthalenes(14, 15) synthesized in our ... 11 was obtained as shown in Scheme 1 by two subsequent Suzuki coupling(21) steps ...