Phytotherapy Research 2011-11-01

Protective effect of components isolated from Lindera erythrocarpa against oxidative stress-induced apoptosis of H9c2 cardiomyocytes.

Jeong Ah Kim, Yi-Sook Jung, Mi-Young Kim, Seo Young Yang, Sohyun Lee, Young Ho Kim

Index: Phytother Res. 25(11) , 1612-7, (2011)

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Abstract

Eight compounds were isolated from the methanol fraction of Lindera erythrocarpa and assessed for their ability to protect H9c2 cardiomyocytes against oxidative stress-induced cell death. Three of the compounds significantly reduced the release of lactate dehydrogenase from H9c2 cardiomyocytes treated with buthionine-[S,R]-sulfoximine and reduced the uptake of propidium iodide by these cells. These effects were concentration-dependent. The three inhibitory compounds were identified as (-)-epicatechin, avicularin and quercitrin by spectroscopic techniques including one- and two-dimensional NMR and mass spectroscopy.Copyright © 2011 John Wiley & Sons, Ltd.