Organic Letters 2004-11-11

Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.

G K Surya Prakash, Jinbo Hu, Ying Wang, George A Olah

Index: Org. Lett. 23th ed., 6 , 4315-4317, (2004)

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Abstract

A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluoromethyl anion ("CF(2)H(-)") equivalent.