Bioorganic & Medicinal Chemistry 2009-06-01

Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives.

Jean L Santos, Paulo R Yamasaki, Chung Man Chin, Célio H Takashi, Fernando R Pavan, Clarice Q F Leite

Index: Bioorg. Med. Chem. 17 , 3795-9, (2009)

Full Text: HTML

Abstract

New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 microg/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis.