Bioorganic & Medicinal Chemistry Letters 2002-06-03

Nicotinanilides as inhibitors of neutrophil chemotaxis.

Neil S Cutshall, Kristin A Kucera, Rocky Ursino, John Latham, Nathan C Ihle

Index: Bioorg. Med. Chem. Lett. 12(11) , 1517-20, (2002)

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Abstract

A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.