Nucleosides, Nucleotides & Nucleic Acids 2007-01-01

A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.

H B Lazrek, J J Vasseur, Jack Secrist, Joachim W Engels

Index: Nucleosides Nucleotides Nucleic Acids 26(8-9) , 1103-6, (2007)

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Abstract

We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.