Chemical Communications 2012-06-14

Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides.

Sheng Wang, Wenxian Xie, Xiu Zhang, Xia Zou, Yan Zhang

Index: Chem. Commun. (Camb.) 48(47) , 5907-9, (2012)

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Abstract

Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.