Journal of Steroid Biochemistry 1981-08-01

Deuterium labelled steroid hormones: syntheses and application in quantitation and endocrinology.

D W Johnson, G Phillipou, R F Seamark

Index: J. Steroid Biochem. 14(8) , 793-800, (1981)

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Abstract

Methods for the syntheses of various multi-deuterated steroid hormones have been summarized and evaluated. Applications of these latter compounds in combination with the technique of gas chromatography/mass spectrometry are described in the general areas of quantitation and human endocrinology, including their potential for the establishment of definitive reference methods or measuring steroid production rates.