Bioorganic & Medicinal Chemistry 1996-01-01

Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase.

Y Nishimura, T Satoh, T Kudo, S Kondo, T Takeuchi

Index: Bioorg. Med. Chem. 4(1) , 91-6, (1996)

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Abstract

N-Acetylgalactosamine-based 1-N-iminosugars, new types of glycosidase inhibitor have been synthesized by modeling on siastatin B, isolated from a Streptomyces culture. The analogues of siastatin B were proved to be potent inhibitors for alpha-N-acetylgalactosaminidase and/or beta-N-acetylglucosaminidase.