Chemistry Letters

One-pot Synthesis of. BETA.-Lactams from Aldimines and Ketene Silyl Acetals by Tandem Lewis Base-catalyzed Mannich-type Addition and Cyclization

E Takahashi, H Fujisawa, T Yanai, T Mukaiyama

Index: Takahashi, Eiki; Fujisawa, Hidehiko; Yanai, Toshiharu; Mukaiyama, Teruaki Chemistry Letters, 2005 , vol. 34, # 2 p. 216 - 217

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Citation Number: 24

Abstract

An efficient method for one-pot synthesis of β-lactams from aldimines and ketene silyl acetals by tandem Lewis base-catalyzed Mannich-type addition and cyclization, namely reaction of benzylideneanilines and trimethylsilyl enolates derived from esters or thioesters was established by using a Lewis base catalyst such as lithium acetate, N-lithio-2- pyrrolidone, potassium salt of phthalimide or lithium methoxide in DMF at room ...