Journal of Surgical Research 2014-05-01

Possible nitric oxide modulation in the protective effects of rutin against experimental head trauma–induced cognitive deficits: behavioral, biochemical, and molecular correlates

Anil Kumar, Puneet Rinwa, Hitesh Dhar

Index: J. Surg. Res. 188(1) , 268-79, (2014)

Full Text: HTML

Abstract

Background Traumatic head injury is turning out to be a major cause of disability and death. Nitric oxide (NO), an intercellular messenger plays a crucial role in the pathophysiology of several neurologic disorders. Therefore, the present study was designed to investigate the effects of rutin, a well-known flavonoid against cognitive deficits and neuroinflammation associated with traumatic head injury and the probable role of NO pathway in this effect.