Organic Letters 2015-05-01

Palladium-Catalyzed C(sp(3))-C(sp(2)) Cross-Coupling of (Trimethylsilyl)methyllithium with (Hetero)Aryl Halides.

Dorus Heijnen, Valentín Hornillos, Brian P Corbet, Massimo Giannerini, Ben L Feringa

Index: Org. Lett. , (2015)

Full Text: HTML

Abstract

The palladium-catalyzed direct cross-coupling of a range of organic chlorides and bromides with the bifunctional C(sp(3))-(trimethylsilyl)methyllithium reagent is reported. The use of Pd-PEPPSI-IPent as the catalyst allows for the preparation of structurally diverse and synthetically versatile benzyl- and allylsilanes in high yields under mild conditions (room temperature) with short reaction times.