Efficient one-pot synthesis of the 2-aminocarbonylpyrrolidin-4-ylthio-containing side chain of the new broad-spectrum carbapenem antibiotic ertapenem

KMJ Brands, RB Jobson, KM Conrad…

Index: Matsumura, Haruki; Bando, Takashi; Sunagawa, Makoto Heterocycles, 1995 , vol. 41, # 1 p. 147 - 160

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Citation Number: 28

Abstract

... Volume: Page: ... A triple-resonance NMR experiment ( 13 C observed with simultaneous 1 H and 31 P decoupling) was used to verify these ... Significant sym-anhydride formation obviously detracts from the maximum achievable yield for 10 in this process. ...