Biochemical and Biophysical Research Communications 2013-11-15

Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice

Kyoung Joo Cho, Hyun Woo Kim, So Yeong Cheon, Jong Eun Lee, Gyung Whan Kim

Index: Biochem. Biophys. Res. Commun. 441(2) , 280-5, (2013)

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Abstract

• Systemic infusion of 3-NP increased ROS and led striatal cell loss. • ASK1 down-regulation decreased striatal cell death without scavenging ROS. • Adding ASK1protein to SOD tg aggravated striatal degeneration. • ASK1 activation induced by ROS is an important step of the 3-NP pathophysiology.