Chemical Communications 2012-06-14

Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas.

Gaosheng Yang, Chongrong Luo, Xiaolong Mu, Tingting Wang, Xin-Yuan Liu

Index: Chem. Commun. (Camb.) 48(47) , 5880-2, (2012)

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Abstract

A three-component cascade reaction of salicylaldehyde, malononitrile/cyanoacetate and nitromethane catalysed by chiral tertiary amino-thioureas was developed, which leads to the production of highly functionalized 2-amino-4H-chromenes in good yields with good to excellent enantioselectivities.