Journal of Natural Products 2008-12-01

Fagraldehyde, a secoiridoid isolated from Fagraea fragrans.

Marie-Caroline Jonville, Marie Capel, Michel Frédérich, Luc Angenot, Georges Dive, Robert Faure, Nadine Azas, Evelyne Ollivier

Index: J. Nat. Prod. 71(12) , 2038-40, (2008)

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Abstract

A secoiridoid aglycone with an atypical skeleton, named fagraldehyde (1), together with several known secoiridoids (gentiopicroside (2), sweroside (3), and swertiamarin (4)) were isolated from the bark and leaves of Fagraea fragrans collected in Cambodia. The conformations of 1 were evaluated on the basis of molecular modeling and NOESY correlations. A hypothetical biogenesis of fagraldehyde was proposed to explain the unusual skeleton. Compound 1 was weakly active in vitro against Plasmodium falciparum.