Organic Letters 2007-07-05

A cyclopropanol-based strategy for subunit coupling: total synthesis of (+)-spirolaxine methyl ether.

Katie A Keaton, Andrew J Phillips

Index: Org. Lett. 9 , 2717, (2007)

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Abstract

A strategy for ketone synthesis with cyclopropanols as intermediates and its application to (+)-spirolaxine methyl ether is described. The synthesis also features an application of Fu's alkyl-alkyl Suzuki coupling.