Organic Letters 2007-05-24

Recoverable PEG-supported copper catalyst for highly stereocontrolled nitroaldol condensation.

Marco Bandini, Maurizio Benaglia, Riccardo Sinisi, Simona Tommasi, Achille Umani-Ronchi

Index: Org. Lett. 9 , 2151, (2007)

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Abstract

A new poly(ethylene glycol)-modified DAT2-Cu(OAc)2 complex smoothly catalyzes a base-free nitroaldol condensation in a highly enantioselective manner (ee up to 93%) also in reagent-grade solvent and in the presence of air. Effective recovery and recycling (up to five runs) of supported catalysts are documented.